Category: PSI Spotlights

Profile articles and images that shine a spotlight on PSI grantees/fellows.

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Dr. Christopher Witiw: Focusing on the Value of Spine Surgery

Degenerative Cervical Myelopathy (DCM)

Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord impairments in adults worldwide. Recent evidence indicates that surgical intervention for DCM is associated with improved function and quality of life, regardless of disease severity. Albeit effective, surgery for DCM remains costly. Moreover, wait times for spine surgery in Ontario remain lengthy and this is likely to continue as the population ages. Health policymakers require an assessment of quality and value of surgery to develop an informed decision and optimize health resource allocation.

Cost-Effectiveness of Surgery for DCM – Dr. Christopher Witiw and Dr. Michael Fehlings

Through PSI’s Resident Research funding stream, Dr. Christopher Witiw, along with his supervisor Dr. Michael G. Fehlings of Toronto Western Hospital, conducted a study to determine the cost effectiveness of surgical intervention for DCM. The investigators found that surgery provided a Headshot - Dr. Christopher Witiwsignificant improvement in quality of life and by using health economic calculations; they determined that 97.9% of interventions are very cost-effective relative to non-operative management. This finding suggests that resource allocation toward improving access to spinal surgery for those with debilitating condition is an effective allocation of resources. These findings will serve to provide surgeons and policymakers with the evidence needed to guide decision-making and optimize healthcare expenditures.

“This resident research grant, which I received from the PSI Foundation was a tremendous resource. The funding was instrumental in providing the means to combine my research training in health economics with my clinical focus on spine surgery to complete this important evaluation of the value of surgery for Degenerative Cervical Myelopathy.”

Impact of the Findings

Dr. Witiw was awarded the highly prestigious North American Spine Society Outstanding Paper Award for the manuscript based upon the findings of the study, which was published in The Spine Journal. Moreover, the data has been presented at numerous international spine surgical conferences and have been honoured with prestigious awards from a number of spinal surgical societies. Furthermore, the findings have been recently incorporated into international surgical guidelines regarding the management of Degenerative Cervical Myelopathy. Despite the success in knowledge translation to the academic spine surgery community thus far, Dr. Witiw believes more is needed to disseminate these findings to those responsible for healthcare resource allocation.

“Much of the care provided by spine surgeons is costly, but at the same time makes a tremendously positive impact on a patient’s quality of life. As healthcare resources become increasingly strained, more research pertaining to cost-effectiveness is needed to empower physicians to work with health policy makers to provide optimal care.”

Future Directions

Dr. Witiw has recently completed his neurosurgical residency training at the University of Toronto and is currently spending 1 year enrolled in a Spinal Neurosurgery Fellowship at Rush University Medical Center in Chicago. Here he is focusing on learning minimally invasive techniques for spine surgery, with the goals of lessening post-operative pain, reducing length of hospital stay and complications and optimizing outcomes. Following this, he plans to return to Toronto to a position as a spine surgeon at the University of Toronto and St. Michael’s Hospital where he hopes to continue his work on studying and improving the value of spine surgery for patients in Ontario.

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Drs. Yaron Finkelstein and Suzanne Schuh: Predictors of Serious Outcomes in Infants with Bronchiolitis

Drs. Yaron Finkelstein and Suzanne Schuh’s PSI grant, BRonchiolitis Epidemiology: Air pollution and Trends of Hospitalization (The BREATH Study) was awarded in December 2014. Since then, their first manuscript, Predictors of Critical Care and Mortality in Bronchiolitis after Emergency Department Discharge, has been accepted for publication in the Journal of Pediatrics. Moreover, its critical findings led to its selection as one of the top four out of more than 3,000 abstract submissions to the annual conference of the Pediatric Academic Societies. This was presented as a platform at the American Pediatric Associations Presidential Plenary on May 7th, 2018, at the Toronto Metro Convention Centre.

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Dr. Nav Persaud: When Advocacy Leads to Change

“A program such as this where that burden is alleviated, it does a lot more than just help you stay afloat financially. The stress that is relieved is a huge benefit. It allows you to have peace of mind. And if you have peace of mind you can build on that.” -CLEAN Meds participant

Imagine having access to a universal health care system but you are unable to treat your condition due to financial burdens. Unfortunately, Canada is one of the only advanced economies with a universal health care system that excludes universal coverage of prescription drugs.

In January 2016, PSI awarded Dr. Nav Persaud, of St. Michael’s Hospital in Toronto, the 2016 Graham Farquharson Knowledge Translation Fellowship. With a focus on addressing health inequalities, Dr. Persaud launched the CLEAN Meds project to assess how better access to life-saving medications for people with low incomes might improve health, control disease, and save Canadians billions of dollars annually.

Dr. Persaud’s recent study published in the Canadian Medical Association Journal indicates that if Canada had a national strategy for publicly funding essential medicines, patients and private drug sponsors would save $3 billion. With four hundred patients currently enrolled in the CLEAN Meds project, measuring the health effects of providing patients with free access to essential medicines who could not previously afford them will be instrumental in shaping public policy.

In May 2018, Dr. Persaud will share the results with public ddecision-makers in the hope that they will pay attention to research findings and views of Canadians to publicly fund a minimal list of essential medicines.

For more information, please click on the following links:

Program
About CLEAN Meds

Publications
Estimated effects of adding universal public coverage of an essential medicines list to existing public drug plans in Canada

Development of a preliminary essential medicines list for Canada

Media
The argument for providing ‘essential medicines’ for free in Canada

Government drug coverage could save Canadians ‘billions,’ study finds

Essential medicines must be available to all Canadians

Podcasts
Huge potential savings from public coverage of essential medicines in Canada

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Dr. Mark Sinyor: Using Data to Help Fight Suicide in Toronto

“Suicide is the number one cause of death from illness from adolescence to mid-life. Unfortunately, the biggest challenge isn’t a lack of programs or services, rather it is identifying high risk groups and understanding the most effective preventative measures.” -Dr. Mark Sinyor

In 2010, Dr. Mark Sinyor of Sunnybrook Health Sciences Centre published the Bloor Viaduct study in the British Medical Journal (Link: http://www.bmj.com/content/341/bmj.c2884.full). Through this study he determined that more had to be done in Toronto to prevent suicide than just building a barrier at the Bloor Street Viaduct bridge. In 2011, PSI launched Dr. Sinyor’s independent research career by awarding him with $20,000 for his Resident Research project titled, “Understanding suicides in Toronto: a comparison of suicide victims with and without a history of suicide attempts.”

The funding was fundamental to collecting and pairing epidemiology and clinical data, which includes information from over 3000 suicides in Toronto. With this kind of information at hand, the database has been a game changer in helping to inform suicide prevention in the city. Researchers, for example, are able to correlate relationships between gender, age groups, and regions of the city with higher rates of suicide. Breaking up this kind of information allows for tailored intervention, which will be key in helping to identify mental illness among different groups, such as in socially isolated elderly or in youth. Essentially, the database is helping to detect people prone to suicide, identify how to treat them, and how to treat suicide in itself. Dr. Sinyor and the research funded by PSI were part of Toronto Public Health’s suicide prevention initiative. In 2015, he organized the first forum in Canada connecting mental health experts, public health policy makers and members of the media to discuss steps to improve public discourse about suicide. Dr. Sinyor also sits on the TTC’s suicide prevention committee.

According to Dr. Sinyor, good treatments exist; however, the community needs to take more of an initiative to recognize, understand and talk about mental illness in order for people to utilize the correct services. With better understanding, particularly in high risk areas, anyone from healthcare workers, friends, family, and teachers can create meaningful change.

If you’re interested in learning more about Dr. Sinyor’s work, please click on the following links:

 

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Dr. Christopher Wallis: Does Testosterone Replacement Therapy Increase Risk of Cardiovascular Disease?

The PSIF Resident Research Grant gave me the opportunity to investigate an issue of interest both to me and the medical community. Through this support, I was able to develop an analysis which goes into greater detail than previously available. In doing so, I worked collaboratively with many researchers who would otherwise not have interacted. While the true importance of this work remains to be seen, this opportunity has greatly enriched my research experience.” – Dr. Christopher Wallis

In 2014, a controversial article published in the Journal of the American Medical Association suggested that testosterone replacement therapy increases cardiovascular risk. Dr. Christopher Wallis of the University of Toronto knew he had access to a wealth of information available in Canadian healthcare databases to address this controversy. Through the support of PSI Foundation, Dr. Wallis was awarded a Resident Research Grant for $17,500 in 2015 in order to further investigate this question in his study titled “A population-based cohort study assessing cardiovascular and oncologic events associated with testosterone replacement therapy.”

Examining all patients over the age of 65 treated with testosterone and untreated, matched patients, Dr. Wallis and colleagues were able to conclude that testosterone treatment over the long-term is associated with a decreased risk of death and cardiovascular events.

Dr. Wallis has now published these results in the Lancet Diabetes & Endocrinology and has shared this information with fellow doctors at international medical meetings and with the public through radio, print and online interviews in Canada and the United States.

While there are limitations to conclusions which can be drawn from these data, this represents an important step in our understanding as well as reassurance to patients receiving and physicians prescribing testosterone. The authors hope that these results will provide the impetus for further research understanding the mechanisms of testosterone’s effect on the cardiovascular system.

For more information, click on the following link:

Long-term treatment key to safe testosterone replacement therapy: study

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Dr. Christine Lee: A Fresh Take on Poop

“Our family wants to thank you for saving the life of our one-hundred-year-old mother by treating her with a fecal transplant. Before this amazing cure, she suffered for seven months with recurring bouts of c-difficile and her health was rapidly deteriorating. She completely recovered from this debilitating disease within 24 hours of the treatment in January.” – Laurie and Jay Cashmore

When you think of poop, does lifesaving come to mind? In 2013, Dr. Christine Lee from McMaster University was awarded with $169,000 for her clinical research study “A prospective randomized double-blind trial of fresh versus frozen-and-thawed human biotherapy for recurrent Clostridium difficile infection.”

Clostridium difficile infection (CDI) occurs when the colon is stripped of good bacteria, typically due to patients taking antibiotics. The use of fresh fecal microbiota transplantation has been the common practice for treatment for recurrent CDI; however, problems related to time involved for screening process and the short window of opportunity to use the specimen have posed as a challenge.

Dr. Lee is overcoming these challenges with her research that proves the feasibility of frozen fecal versus fresh fecal in several areas:

Emotionally, there is a restoration of health and quality of life for many patients, as well as their family members who are the ones caring for the patients.

Economically, the financial burden is lifted for patients and families, as there is a high cost associated with prolonged stays and long-term use of medication (up to $30,000).

Within the healthcare industry, significant reduction in overall length of hospital stay not only minimizes the risk of transmission to other patients, but also, reduces costs. For example, in treating 150 patients over a span of 1.5 years there was a financial savings of $3.3 million.

Next steps are to offer Lyophilized, which is freeze-and-dried stool that can be sent anywhere, making it available more widely.

If you’re looking to become a donor and/or interested in more information, please do not hesitate to contact Dr. Christine Lee at clee@mcmaster.ca.

To find out more, take a look at these links:

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Dr. Darren Yuen: PSI’s First New Investigator Grant Recipient

Dr. Yuen is a kidney doctor and scientist at St. Michael’s Hospital in Toronto. His major research interest is the study of kidney scarring, a process that is ultimately responsible for nearly all cases of kidney failure.

There is currently no good test to detect this scarring. The best test available is a needle biopsy, which is associated with significant bleeding risks, requires a day of monitoring, and can not sample and analyze the entire kidney. A new type of MRI called “MR elastography” has been proven to accurately measure scarring in the liver, but not yet in the kidney. It does not need any injections, can be done in 30 minutes, and may be able to measure scar throughout the entire kidney without needles.

The Physicians’ Services Incorporated Foundation is supporting a research project in which Dr. Yuen and colleagues are testing the potential ability of magnetic resonance imaging (MRI) to measure kidney scarring, comparing it against biopsy analysis. Together with Dr. Anish Kirpalani, a radiologist at St. Michael’s Hospital, and a team of kidney doctors, pathologists, and imaging experts, Dr. Yuen hopes to determine if MRI can measure scar in the transplanted kidneys of people with both normal and abnormal transplant function. This could drastically change how a doctor treats transplant failure.

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Drs. Erick Duan and John Centofanti: Improving communication, safety and education in the ICU

“The PSI Foundation resident research grant was pivotal in allowing us to study the use of a Daily Goals Checklist in our intensive care unit and learn how this tool could benefit safe patient care, communication, and education. This was the first major peer-reviewed grant funding we have received, and through this project we gained tremendous, first-hand experience conducting rigorous clinical research under the guidance of Dr. Deborah Cook. With the support of the PSI Foundation funding, this project has served as a take-off point for our careers in critical care research.”

In 2012, Drs. Erick Duan and John Centofanti received a Resident Research Grant for $13,000 for their study “ICU Daily Goals Checklist: a mixed methods analysis of effects on communication & patient care.” This project was supervised by Dr. Deborah Cook at McMaster University. Drs. Duan and Centofanti published the results of their study in Critical Care Medicine. They have presented this research in both oral and poster form, including at the 2015 PSI Annual General Meeting, where they won an award for best poster. (Please see citations below.)

Dr. Duan completed medical school and residency at McMaster University. He is finishing fellowship training in Critical Care Medicine and will continue on to the Clinician-Investigator Program, also at McMaster, while beginning a Master’s degree in Health Research Methodology. Dr. Centofanti completed medical school and residency in Anesthesiology at McMaster University. He has begun a Critical Care Medicine fellowship, and will also be completing a Master’s degree in Health Administration at McMaster.

Publication:

  • Centofanti JE, Duan EH, Hoad NC, et al. Use of a Daily Goals Checklist for Morning ICU Rounds. Critical Care Medicine 2014;42(8):1797–803

Presentations:

  • Centofanti J, Duan E, Hoad N, Swinton N, Perri D, Waugh L, Soth M, Cook D. Improving an ICU Daily Goals Checklist: Integrated and End-of-Grant Knowledge Translation. Oral Presentation. Canadian Critical Care Forum, Toronto, ON. October 28, 2014.
  • Duan EH, Centofanti J, Hoad N, Waugh L, Perri D, Cook D. Use Of A Daily Goals Checklist For Morning Intensive Care Unit Rounds: A Mixed-Methods Study. Am J Respir Crit 2014;189:A5250.
  • Hoad N, Duan E, Centofanti J, Waugh L, Perri D, Cook D. Maximizing Staff Involvement To Refine An Icu Rounding Tool. Am J Respir Crit. 2014;189:A5254.
  • Centofanti J, Duan E, Hoad N, Waugh L, Perri D, Cook D. 603: RESIDENTS’ PERSPECTIVES ON A DAILY GOALS CHECKLIST: A MIXED-METHODS STUDY. Critical Care Medicine 2012;40(12):1.
  • Hoad N, Centofanti J, Duan E, Perri D, Waugh L, Cook D. 814: A MULTIDISCIPLINARY ICU COMMUNICATION CHECKLIST: A QUALITATIVE STUDY. Critical Care Medicine 2012;40(12):1.
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Dr. Fiona Kouyoumdjian: Research Into the Health of the Incarcerated

“The PSIF Resident Research Grant was the first project funding that I ever received, and it allowed me to answer a question from my clinical work with people who were incarcerated. Through that project, I learned about prison health research in Canada, and I developed relationships with people working in this field. I am now building on this foundation to develop a program of research focused on improving the health and health care of people who are incarcerated in Canada.”

In 2008, Dr. Fiona Kouyoumdjian received a Resident Research Grant for $18,000 for her study “The prevalence of gonorrhoea and chlamydia in male inmates in a provincial correctional facility in Ontario.” This project was supervised by Dr. Cheryl Main at McMaster University. Dr. Kouyoumdjian has published three papers in peer-reviewed journals based on this project in the International Journal of STD & AIDS and the Canadian Journal of Public Health. The third is in press (citation: F. G. Kouyoumdjian, L. M. Calzavara, L. Kiefer, C. Main, S.J. Bondy. Drug use prior to incarceration and associated socio-behavioural factors in males in a provincial correctional facility in Ontario, Canada. Canadian Journal of Public Health. In press). Dr. Kouyoumdjian presented her research as a poster presentation at the 2014 PSI Annual General Meeting.

Dr. Kouyoumdjian completed medical school at Dalhousie University, a Master of Public Health at the Johns Hopkins Bloomberg School of Public Health, and residency in Public Health and Preventive Medicine and a PhD in Epidemiology at the Dalla Lana School of Public Health at the University of Toronto. She is currently a Postdoctoral Fellow at the Centre for Research on Inner City Health at St. Michael’s Hospital in Toronto, with Dr. Stephen Hwang as her supervisor, and she works as a Family Physician at a provincial correctional facility. She has a CIHR Fellowship from 2013 to 2016.

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Dr. Marc Jeschke: Improving Outcomes of Burn Injury

How did the PSI Funding Help with the Study?

The funding via the PSI Foundation enabled groundbreaking work to provide evidence that glucose can be controlled in severely-burned patients via novel perturbations and that this modulation of glucose is beneficial in terms of outcomes after a burn injury. These results are ultimately leading to an ongoing large prospective clinical trial which hopefully will confirm the benefit of the perturbation.

Description:

PSI Foundation funded Dr. Marc Jeschke of Sunnybrook Health Sciences Centre in Toronto for his study Glucose control in severely burned patients: mechanisms and therapeutic potential. In 2010, PSI approved $165,000 for his 2 year study.

Dr. Jeschke is a Professor in the Department of Surgery and the Department of Immunology at the University of Toronto. He is also the Director of the Ross Tilley Burn Centre and Senior Scientist at the Sunnybrook Research Institute.

Dr. Jeschke has had several papers resulting from this research, including publications in Lancet and the Annals of Surgery.

Publications

  1. Abdullahi A, Amini-Nik S, Jeschke MG. Animal models in burn research. Cell Mol Life Sci. 2014 Apr. 2014 Apr 9. [Epub ahead of print].
  2. Stanojcic M, Chen P, Harrison RA, Wang V, Antonyshyn J, Zúñiga-Pflücker JC, Jeschke MG. Leukocyte Infiltration and Activation of the NLRP3 Inflammasome in White Adipose Tissue Following Thermal Injury. Crit Care Med. 2014 Mar. 2014 Feb 26. [Epub ahead of print].
  3. Diao L, Marshall AH, Dai X, Bogdanovic E, Abdullahi A, Amini-Nik S, Jeschke MG. Burn Plus Lipopolysaccharide Augments Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation and Reduces PGC-1α in Liver. Shock. 2014 Feb. Feb;41(2):138-44. doi: 10.1097/SHK.0000000000000075.
  4. Jeschke MG, Pinto R, Herndon DN, Finnerty CC, Kraft R. Hypoglycemia Is Associated With Increased Postburn Morbidity and Mortality in Pediatric Patients. Critical Care Medicine. 2013 Dec. 2013 Dec 23. [Epub ahead of print].
  5. Jeschke MG, Herndon DN. Burns in children: standard and new treatments. Lancet. 2013 Sep. Lancet. 2013 Sep 10. doi:pii: S0140-6736(13)61093-4. 10.1016/S0140-6736(13)61093-4. [Epub ahead of print].
  6. Jeschke MG. Clinical review: Glucose control in severely burned patients – current best practice. Crit Care. 2013 Jul. 2013 Jul 25;17(4):232. [Epub ahead of print].
  7. Jeschke MG, Finnerty CC, Kulp GA, Kraft R, Herndon DN. Can we use C-reactive protein levels to predict severe infection or sepsis in severely burned patients? Int J Burns Trauma. 2013 Jul. 2013 Jul 8;3(3):137-43. Print 2013.
  8. Kraft R, Herndon DN, Mlcak RP, Finnerty CC, Cox RA, Williams FN, Jeschke MG. Bacterial respiratory tract infections are promoted by systemic hyperglycemia after severe burn injury in pediatric patients. Burns. 2013 Sep. 2013 Sep 25. doi:pii: S0305-4179(13)00229-5. 10.1016/j.burns.2013.07.007. [Epub ahead of print].
  9. Hiyama Y, Marshall AH, Kraft R, Arno A, Jeschke MG. Fenofibrate does not affect burn-induced hepatic endoplasmic reticulum stress. J Surg Res. 2013 Jul. 2013 Jul 4. doi:pii: S0022-4804(13)00659-8. 10.1016/j.jss.2013.06.029. [Epub ahead of print].
  10. Jeschke MG, Gauglitz GG, Finnerty CC, Kraft R, Mlcak RP, Herndon DN. Survivors Versus Nonsurvivors Postburn: Differences in Inflammatory and Hypermetabolic Trajectories. Ann Surg. 2013 Apr. 2013 Apr 10. [Epub ahead of print].
  11. Brooks NC, Marshall AH, Qa’aty N, Hiyama Y, Boehning D, Jeschke MG. XBP-1s is Linked to Suppressed Gluconeogenesis in the Ebb Phase of Burn Injury. Mol Med. 2013 Mar 15. doi: 10.2119/molmed.2012.00348. [Epub ahead of print].
  12. Kraft R, Herndon DN, Finnerty CC, Shahrokhi S, Jeschke MG. Occurrence of Multiorgan Dysfunction in Pediatric Burn Patients: Incidence and Clinical Outcome. Annals of Surgery. 2013 Mar 18. [Epub ahead of print].
  13. Marshall AH, Brooks NC, Hiyama Y, Qa’aty N, Al-Mousawi A, Finnerty CC, Jeschke MG. Hepatic Apoptosis Postburn Is Mediated by C-Jun N-Terminal Kinase 2. Shock. 2013 Feb;39(2):183-8.
  14. Hiyama Y, Marshall AH, Kraft R, Qa’aty N, Arno A, Herndon DN, Jeschke MG. The Effects of Metformin on Burn Induced Hepatic Endoplasmic Reticulum Stress in Male Rats. Mol Med. 2013 Mar 5;19:1-6.
  15. Kraft R, Herndon DN, Finnerty CC, Hiyama Y, Jeschke MG. Association of Postburn Fatty Acids and Triglycerides with Clinical Outcome in Severely Burned Children. J Clin Endocrinol Metab. 2013 Jan;98(1):314-21. doi: 10.1210/jc.2012-2599. Epub 2012 Nov 12.
  16. Kulp GA, Tilton RG, Herndon DN, Jeschke MG. Hyperglycemia exacerbates burn-induced liver inflammation via noncanoncial NF-κB pathway activation. Molecular Medicine. 2012 Sep 7;18:948-56.
  17. Jeschke MG*, Williams FN*, Finnerty CC, Rodriguez N, Kulp GA, Ferrando AA, Norbury WB, Suman OE, Kraft R, Branski LK, Al-mousawi A, Herndon DN. The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes. PLoS One. 2012;7(5):e35465. Epub 2012 May 11.
  18. Song J, Finnerty CC, Herndon DN, Kraft R, Boehning D, Brooks NC, Jeschke MG. Thermal injury activates the eEF2K-dependent eEF2 pathway in pediatric patients. JPEN. 2012 Sep;36(5):596-602.

Papers Published on Foundation Funded Projects:

Palmitate differentially regulates the polarization of differentiating and differentiated macrophages

Reliable scar scoring system to assess photographs of burn patients

Predictive value of IL-8 for sepsis and severe infections after burn injury: a clinical study

Healthcare costs of burn patients from homes without fire sprinklers

Stress induced insulin resistance in regards to cellular organelles, inflammasome and inflammation and lipids

Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury

  • Crit Care Med. 2014 Jun;42(6):1357-64

Ex vivo expansion of hematopoietic stem and progenitor cells: recent advances

  • World J Hematol 2014 May 6; 3(2): 18-28

Hypoglycemia is associated with increased postburn morbidity and mortality in pediatric patients

  • Crit Care Med. 2014 May;42(5):1221-31

Survivors versus nonsurvivors postburn: differences in inflammatory and hypermetabolic trajectories

  • Ann Surg. 2014 Apr;259(4):814-23

Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1α in liver

  • Shock. 2014 Feb;41(2):138-44

The use of dermal substitutes in burn surgery: acute phase

  • Wound Repair Regen. 2014 Jan;22(1):14-22

Propranolol Improves Impaired Hepatic Phosphatidylinositol 3-Kinase/Akt Signaling after Burn Injury

  • Mol Med, 2012 May 9;18:707-11

Hyperglycemia exacerbates burn-induced liver inflammation via noncanonical nuclear factor-κB pathway activation

  • Mol Med, 2012 Sep 7;18:948-56

The Effects of Metformin on Burn Induced Hepatic Endoplasmic Reticulum Stress in Male Rats

  • Mol Med, 2013 Jan 16. Epub ahead of print]

Norepinephrine inhibits macrophage migration by decreasing CCR2 expression

  • PLoS ONE 8(7):e69167

Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes

  • J Cell Mol Med 2012 Mar;16(3):437-44

XBP-1s Is Linked to Suppressed Gluconeogenesis in the Ebb Phase of Burn Injury

  • Mol Med 2013 May 20;19:72-8

Genomic responses in mouse models poorly mimic human inflammatory diseases

  • Jeschke, M.G.

Enteral nutrition support in burn care: a review of current recommendations as instituted in the Ross Tilley Burn Centre

  • Jeschke, M.G.

Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study

  • Lancet, 2012 Mar 17;379(9820):1013-21

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